Well even with all the naysayers, the duct tape experiment had to commence!
I realize that it isn't entirely representative what the difference will be when it is welded shut but it should give a reasonable idea......on with the pics.
So as for the results of my tests, which are by no means conclusive.......
Door opening ease - UNCHANGED
Door closing ease - UNCHANGED
Wind Noise - UNCHANGED
Sunroof Wind Noise - UNCHANGED
Sense of cabin pressure when closing or opening doors - UNCHANGED
I can basically see no noticeable difference in any area at this time.
I do see it definately being related to the air\AC\Heater because, and correct me if I am wrong here, in order for the air to flow to the back of the vehicle there needs to be some suction pulling it. Removing the vent essentially leaves no way for the air to circulate to the back of the vehicle. And since there is no rear vents that i can see.....this would mean that the rear passengers and cargo area wouldn't get air circulated to them nearly as efficiently.
This definately falls into line with H3Lady's post and makes sense engineering wise as well. Also makes logic sense for the rear defroster condensing too.
So I am still going ahead with this project. If I find it noticeably uncomfortable for the air circulation then I will consider a vent relocation, perhaps in the fender well.